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I'm not really qualified on this subject because my experience with Python is liminted, but my opinion is like this.
Perl is a language where you Can Do It. Its creators did a pretty good job of "making easy things easy and difficult things possible" (their motto). If you're familiar with programming constructs you find Perl a language where doing things is very intuitive.
On the other hand, this comes at a price. Perl is a language with a very confusing structure. If you want to create complex, structured apps, Perl's lack of clear structure will hinder you.
My personal beef with Perl (as a Windows man) is its strong UNIX bias. Again, this makes many things easy, since UNIX has lots of cool functionality. But if you don't like to do things the UNIX way you have to resort to contortions.
In my experience at least, Python does not suffer from these issues. But as a result it does not have the intuitiveness and ease that Perl has. However Python does have the powerful high-level functionality of Perl.
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